Impaired IgE Activation-induced Cytokine and Chemokine Production but not Degranulation in Protein Kinase D3 (PKD3)-deficient Mast Cells

Impaired IgE Activation-induced Cytokine and Chemokine Production but not Degranulation in Protein Kinase D3 (PKD3)-deficient Mast Cells

Activation of mouse bone marrow-derived mast cells (BMMC) leads to activation of PKD1, and pharmacologic inhibition of the PKD family suppresses activation-induced increases in CCL2 mRNA and released protein but not the secretory granule mediator beta-hexosaminidase.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of allergy and clinical immunology 2009-02, Vol.123 (2), p.S195-S195
Hauptverfasser: Legere, H.J, Katz, H.R
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Chemokines
Cytokines
Kinases
Proteins
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Beschreibung
Zusammenfassung:Activation of mouse bone marrow-derived mast cells (BMMC) leads to activation of PKD1, and pharmacologic inhibition of the PKD family suppresses activation-induced increases in CCL2 mRNA and released protein but not the secretory granule mediator beta-hexosaminidase.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2008.12.743