Drug reaction to ceftriaxone in a child with X-linked agammaglobulinemia

The initial reaction was difficult to differentiate from an IgE-mediated reaction, but the clinical course was indicative of an adverse drug reaction, inasmuch as an additional dose resulted in exacerbation of the cutaneous symptoms. Because T cells have been implicated in such adverse drug reactions, in vivo evidence of T-cell involvement was sought.