Enhanced synergy between fluticasone propionate and salmeterol inhaled from a single inhaler versus separate inhalers

To the Editor: We read with interest the recent meta-analysis of Nelson et al suggesting enhanced synergy between fluticasone and salmeterol delivered from a single inhaler versus separate combination inhalers.1 The basis for this conclusion was from the primary outcome variable for all four studies...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2004, Vol.113 (1), p.178-178
Hauptverfasser:	Lipworth, Brian J., Fardon, Tom C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Albuterol - administration & dosage Albuterol - analogs & derivatives Androstadienes - administration & dosage Asthma Asthma - drug therapy Asthma - physiopathology Bronchodilator Agents - administration & dosage Clinical Trials as Topic Drug Synergism Drug Therapy, Combination Fluticasone Humans Nebulizers and Vaporizers Quality of life Salmeterol Xinafoate Studies Treatment Outcome
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Beschreibung
Zusammenfassung:	To the Editor: We read with interest the recent meta-analysis of Nelson et al suggesting enhanced synergy between fluticasone and salmeterol delivered from a single inhaler versus separate combination inhalers.1 The basis for this conclusion was from the primary outcome variable for all four studies, which was the change in baseline from morning peak flow over 12 weeks.
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2003.10.035