Ozone enhances markers of innate immunity and antigen presentation on airway monocytes in healthy individuals

The importance of antigen presentation is increasingly recognized not only in development of allergic responses but also in maintaining TH2 inflammation in the airways.7 We have reported that inhalation challenge with ambient air particles3 or endotoxin2 stimulates surface expression of molecules im...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of allergy and clinical immunology 2007-09, Vol.120 (3), p.719-722
Hauptverfasser:	Lay, John C., DVM, PhD, Alexis, Neil E., PhD, Kleeberger, Steven R., PhD, Roubey, Robert A.S., MD, Harris, Bradford D., MD, Bromberg, Philip A., MD, Hazucha, Milan J., MD, PhD, Devlin, Robert B., PhD, Peden, David B., MD, MS
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology Antigen presentation Antigen Presentation - drug effects Antigen Presentation - immunology B7-2 Antigen - drug effects B7-2 Antigen - metabolism Biomarkers - analysis Blood CD11b Antigen - drug effects CD11b Antigen - metabolism Cell growth Double-Blind Method Environmental protection Female Flow Cytometry Genotype & phenotype HLA-DR Antigens - drug effects HLA-DR Antigens - metabolism Humans Immunity, Innate - drug effects Lipopolysaccharide Receptors - drug effects Lipopolysaccharide Receptors - metabolism Lung - cytology Lung - immunology Macrophages - drug effects Macrophages - metabolism Male Monocytes - drug effects Monocytes - immunology Monocytes - metabolism Neutrophils - drug effects Neutrophils - metabolism Ozone - toxicity Receptors, IgG - drug effects Receptors, IgG - metabolism Respiratory Function Tests Sputum - cytology Sputum - immunology Studies
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The importance of antigen presentation is increasingly recognized not only in development of allergic responses but also in maintaining TH2 inflammation in the airways.7 We have reported that inhalation challenge with ambient air particles3 or endotoxin2 stimulates surface expression of molecules important for innate immunity (CD11b, and membrane-bound [m]CD14) and antigen presentation (CD80, CD86 and HLA-DR) on airway monocytic cells.
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2007.05.005