Hypersensitivity to lansoprazole and rabeprazole with tolerance to other proton pump inhibitors

Omeprazole is the first drug in this class. Since it was introduced in 1989, several other PPIs have emerged: lansoprazole, rabeprazole, and pantoprazole. Proton pump inhibitors are modified benzimidazoles with a pyridine ring, differing by virtue of substitutions on both rings (Fig 1). [...]omepraz...

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Veröffentlicht in:Journal of allergy and clinical immunology 2006-03, Vol.117 (3), p.707-708
Hauptverfasser: Pérez Pimiento, A.J., Prieto Lastra, L., Rodríguez Cabreros, M.I., González Sánchez, L.A., Mosquera, M. Rodríguez, Cubero, A. García
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container_end_page 708
container_issue 3
container_start_page 707
container_title Journal of allergy and clinical immunology
container_volume 117
creator Pérez Pimiento, A.J.
Prieto Lastra, L.
Rodríguez Cabreros, M.I.
González Sánchez, L.A.
Mosquera, M. Rodríguez
Cubero, A. García
description Omeprazole is the first drug in this class. Since it was introduced in 1989, several other PPIs have emerged: lansoprazole, rabeprazole, and pantoprazole. Proton pump inhibitors are modified benzimidazoles with a pyridine ring, differing by virtue of substitutions on both rings (Fig 1). [...]omeprazole and pantoprazole have respectively a methoxy and a difluoromethoxy chain in their benzimidazole rings, whereas lansoprazole and rabeprazole have no modifications in that ring, but their pyridine rings have respectively a trifluoroethoxy and methoxypropoxy chain.
doi_str_mv 10.1016/j.jaci.2005.11.001
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subjects 2-Pyridinylmethylsulfinylbenzimidazoles
Adult
Benzimidazoles - adverse effects
Cross Reactions
Drug dosages
Drug Hypersensitivity - etiology
Drug Hypersensitivity - immunology
Drug therapy
Enzyme Inhibitors - adverse effects
Female
Humans
Lansoprazole
Omeprazole - adverse effects
Omeprazole - analogs & derivatives
Proton Pump Inhibitors
Rabeprazole
Skin Tests
title Hypersensitivity to lansoprazole and rabeprazole with tolerance to other proton pump inhibitors
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