Hypersensitivity to lansoprazole and rabeprazole with tolerance to other proton pump inhibitors

Omeprazole is the first drug in this class. Since it was introduced in 1989, several other PPIs have emerged: lansoprazole, rabeprazole, and pantoprazole. Proton pump inhibitors are modified benzimidazoles with a pyridine ring, differing by virtue of substitutions on both rings (Fig 1). [...]omeprazole and pantoprazole have respectively a methoxy and a difluoromethoxy chain in their benzimidazole rings, whereas lansoprazole and rabeprazole have no modifications in that ring, but their pyridine rings have respectively a trifluoroethoxy and methoxypropoxy chain.