Risks and benefits of combining aspirin with anticoagulant therapy in patients with atrial fibrillation: An exploratory analysis of stroke prevention using an oral thrombin inhibitor in atrial fibrillation (SPORTIF) trials

Aspirin is used in combination with anticoagulant therapy in patients with atrial fibrillation (AF), but evidence of additional efficacy is not available. We compared ischemic events and bleeding in the SPORTIF III and IV randomized trials of anticoagulation with warfarin (international normalized r...

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Veröffentlicht in:	The American heart journal 2006-11, Vol.152 (5), p.967-973
Hauptverfasser:	Flaker, Greg C., Gruber, Michael, Connolly, Stuart J., Goldman, Steven, Chaparro, Sandra, Vahanian, Alec, Halinen, Matti O., Horrow, Jay, Halperin, Jonathan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anticoagulants Anticoagulants - adverse effects Anticoagulants - therapeutic use Aspirin - adverse effects Aspirin - therapeutic use Atrial Fibrillation - drug therapy Azetidines - adverse effects Azetidines - therapeutic use Benzylamines - adverse effects Benzylamines - therapeutic use Biological and medical sciences Cardiac arrhythmia Cardiac dysrhythmias Cardiology. Vascular system Drug therapy Drug Therapy, Combination Embolism - prevention & control Female Heart Heart attacks Hemorrhage - chemically induced Humans Male Medical sciences Middle Aged Myocardial Infarction - prevention & control Myocardial Ischemia - prevention & control Neurology Platelet Aggregation Inhibitors - adverse effects Platelet Aggregation Inhibitors - therapeutic use Randomized Controlled Trials as Topic Risk Assessment Stroke Stroke - prevention & control Treatment Outcome Vascular diseases and vascular malformations of the nervous system Warfarin - adverse effects Warfarin - therapeutic use
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Zusammenfassung:	Aspirin is used in combination with anticoagulant therapy in patients with atrial fibrillation (AF), but evidence of additional efficacy is not available. We compared ischemic events and bleeding in the SPORTIF III and IV randomized trials of anticoagulation with warfarin (international normalized ratio 2-3) or fixed-dose ximelagatran. Low-dose aspirin (
ISSN:	0002-8703 1097-6744
DOI:	10.1016/j.ahj.2006.06.024