Proton pump inhibitors and clopidogrel: A difficult dilemma

Proton pump inhibitors and clopidogrel: A difficult dilemma

Siller-Matula et al should be congratulated for their efforts to shed more light on the difficult dilemma of opting for an increased risk of upper gastrointestinal hemorrhage or for a potential increased risk of thrombosis, but a solution for this problem is not provided. [...]a convincing pharmacol...

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Veröffentlicht in:The American heart journal 2009-06, Vol.157 (6), p.e43-e43
Hauptverfasser: van Werkum, Jochem W, ten Berg, Jurriën M, Bredenoord, Albert J
Format: Artikel
Sprache:eng
Schlagworte:
2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology
Acute coronary syndromes
Cardiovascular
Confidence intervals
Drug Interactions
Drug therapy
Gastrointestinal Hemorrhage - prevention & control
Humans
Omeprazole - pharmacology
Platelet Aggregation Inhibitors - pharmacology
Proton Pump Inhibitors - pharmacology
Thrombosis - prevention & control
Ticlopidine - analogs & derivatives
Ticlopidine - pharmacology
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Zusammenfassung:Siller-Matula et al should be congratulated for their efforts to shed more light on the difficult dilemma of opting for an increased risk of upper gastrointestinal hemorrhage or for a potential increased risk of thrombosis, but a solution for this problem is not provided. [...]a convincing pharmacological explanation for the observed differences between the PPIs, studied is also lacking.
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2009.03.014