Stem Cells: From Epigeneticsto microRNAs

Stem Cells: From Epigeneticsto microRNAs

The complexity and cellular diversity of the adult brain arises from the proliferation and differentiation of a small number of stem cells. The intrinsic state of stem cells depends on their spatial and temporal history and affects their responsiveness to extrinsic signals from the microenvironment....

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2005-05, Vol.46 (3), p.363
Hauptverfasser: Cheng, Li-Chun, Tavazoie, Masoud, Doetsch, Fiona
Format: Artikel
Sprache:eng
Schlagworte:
Chromatin
DNA methylation
Embryos
Epigenetics
Gene expression
Neurogenesis
Stem cells
Transcription factors
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container_title Neuron (Cambridge, Mass.)
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creator Cheng, Li-Chun
Tavazoie, Masoud
Doetsch, Fiona
description The complexity and cellular diversity of the adult brain arises from the proliferation and differentiation of a small number of stem cells. The intrinsic state of stem cells depends on their spatial and temporal history and affects their responsiveness to extrinsic signals from the microenvironment. Stem cell self-renewal and differentiation along neuronal and glial lineages are defined by the dynamic interplay between transcription, epigenetic control, and posttranscriptional regulators, including microRNAs, whose key role in stem cell biology is just emerging.
doi_str_mv 10.1016/j.neuron.2005.04.027
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source Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Chromatin
DNA methylation
Embryos
Epigenetics
Gene expression
Neurogenesis
Stem cells
Transcription factors
title Stem Cells: From Epigeneticsto microRNAs
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