Stem Cells: From Epigeneticsto microRNAs

Stem Cells: From Epigeneticsto microRNAs

The complexity and cellular diversity of the adult brain arises from the proliferation and differentiation of a small number of stem cells. The intrinsic state of stem cells depends on their spatial and temporal history and affects their responsiveness to extrinsic signals from the microenvironment....

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2005-05, Vol.46 (3), p.363
Hauptverfasser: Cheng, Li-Chun, Tavazoie, Masoud, Doetsch, Fiona
Format: Artikel
Sprache:eng
Schlagworte:
Chromatin
DNA methylation
Embryos
Epigenetics
Gene expression
Neurogenesis
Stem cells
Transcription factors
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Beschreibung
Zusammenfassung:The complexity and cellular diversity of the adult brain arises from the proliferation and differentiation of a small number of stem cells. The intrinsic state of stem cells depends on their spatial and temporal history and affects their responsiveness to extrinsic signals from the microenvironment. Stem cell self-renewal and differentiation along neuronal and glial lineages are defined by the dynamic interplay between transcription, epigenetic control, and posttranscriptional regulators, including microRNAs, whose key role in stem cell biology is just emerging.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2005.04.027