Nickel-Catalyzed Csp2Csp3 Bond Formation by CarbonFluorine Activation

Nickel-Catalyzed Csp2Csp3 Bond Formation by CarbonFluorine Activation

We report herein a general catalytic method for Csp2Csp3 bond formation through CF activation. The process uses an inexpensive nickel complex with either diorganozinc or alkylzinc halide reagents, including those with [beta]-hydrogen atoms. A variety of fluorine substitution patterns and functional...

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Veröffentlicht in:Chemistry : a European journal 2014-03, Vol.20 (11), p.3162
Hauptverfasser: Sun, Alex D, Leung, Kaylyn, Restivo, Anita D, LaBerge, Nicole A, Takasaki, Harumi, Love, Jennifer A
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Nickel
Reagents
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Zusammenfassung:We report herein a general catalytic method for Csp2Csp3 bond formation through CF activation. The process uses an inexpensive nickel complex with either diorganozinc or alkylzinc halide reagents, including those with [beta]-hydrogen atoms. A variety of fluorine substitution patterns and functional groups can be readily incorporated. Sequential reactions involving different precatalysts and coupling partners permit the synthesis of densely functionalized fluorinated building blocks. [PUBLICATION ABSTRACT]
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201303809