Triazole-Linked Analogues of DNA and RNA (TLDNA and TLRNA): Synthesis and Functions

Click chemistry has provided us with access to DNA and RNA analogues with non‐natural triazole internucleoside linkages. The bond periodicity of the oligonucleotides was designed to enforce duplex formation with natural congeners, and the non‐cleavable linkages protect the oligomers against nuclease digestion. This account reviews the progress of the triazole‐linked analogues over the past five years. Reinforced by their synthetic robustness, these analogues may find various utilities as tools for exploratory research. Click chemistry has allowed us access to DNA and RNA analogues with non‐natural triazole internucleoside linkages. The bond periodicity of the oligonucleotides was designed to enforce duplex formation with natural congeners, and the non‐cleavable linkages protect the oligomers against nuclease digestion. The progress of these triazole‐linked analogues over the past five years is reviewed. Reinforced by their synthetic robustness, these analogues may find various uses as tools for exploratory research.