MYELOPEROXIDASE AND GLUTAMATE-CYSTEINE LIGASE POLYMORPHISMS IN TYPE 2 DIABETES MELLITUS: A PRELIMINARY STUDY / POLIMORFIZMI MIJELOPEROKSIDAZE I GLUTAMAT-CISTEIN LIGAZE U DIABETES MELLITUSU TIPA 2: PRELIMINARNA STUDIJA
Background: Oxidative stress can accompany the physio- pathology of diabetes mellitus. Myelopercecidase and gluta- mate-cysteine ligase catalytic subunit are two important sub- stances which are connected with the maintaining of the redox balance in the body. In this study, the association be- tween...
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| creator | Eksi, Yunus Emre Karaali, Zeynep Ermig Incekara, Kutiuhan Ergen, H. Arzu |
| description | Background: Oxidative stress can accompany the physio- pathology of diabetes mellitus. Myelopercecidase and gluta- mate-cysteine ligase catalytic subunit are two important sub- stances which are connected with the maintaining of the redox balance in the body. In this study, the association be- tween diabetes, lipid levels, myeloperoxidase -463G/A, and the glutamate-cysteine ligase catalytic subunit -3506A/G gene polymorphisms have been investigated.
Methods: Frequencies of genotypes and alleles have been assessed using PCR-RFLP techniques in 90 type 2 diabetic patients and 70 healthy controls. Results: We found an association between myeloperoxidase -463 G/A genotype distributions (p=0.023) and allele distri- butions (p=0.009) in the study groups. In addition, there is a significant difference for each of the genotype (p=0.014) and allele (p=0.007) distributions for the glutamate-cysteine ligase catalytic subunit -3506A/G polymorphism.
Conclusions: Our study reveals the first data about the myeloperoxidase -463G/A and glutamate-cysteine ligase catalytic subunit -3506A/G gene polymorphisms for type 2 diabetes and we believe that this work will play a pioneering role for further studies.
Uvod: Fiziopatologiju diabetes mellitusa može pratiti oksida- trvni stres. Katalitičke podjedinice mijeloperoksidaze i gluta- mat-cistein ligaze su dve važne supstance koje su povezane sa održavanjem redoks ravnoteže u telu. U ovoj studiji, ispi- tivana je veza između dijabetesa, n'rvoa lipida i genskih poli- morfizama -463G/A mijeloperoksidaze i -3506A/G katali- tičke podjedinice glutamat-cistein ligaze.
Metode: Učestalost genotipova i alela određena je pomoću tehnika PCR-RFLP kod 90 pacijenata sa dijabetesom tipa 2 i 70 zdravih kontrolnih subjekata.
Rezultati: Otkrili smo povezanost između distribucija ge- notipa (p=0,023) i distribucija alela (p=0,009) -463 G/A mijeloperoksidaze u proučavanim grupama. Pored toga, postoji značajna razlika za svaku od distribucija genotipova (р=0,014) i alela (p=0,007) za polimorfizam katalitičke podjedinice -3506A/G glutamat-cistein ligaze.
Zaključak: ^laša studija otkriva prve podatke o genskim poli- morfizmima -463G/A mijebperoksidaze i -3506A/G katali- tičke podjedinice glutamat-cistein ligaze za dijabetes tipa 2 i verujemo da će ovaj rad imati pionirsku ulogu za buduće studije. |
| doi_str_mv | 10.2478/jomb-2013-0022 |
| format | Article |
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Methods: Frequencies of genotypes and alleles have been assessed using PCR-RFLP techniques in 90 type 2 diabetic patients and 70 healthy controls. Results: We found an association between myeloperoxidase -463 G/A genotype distributions (p=0.023) and allele distri- butions (p=0.009) in the study groups. In addition, there is a significant difference for each of the genotype (p=0.014) and allele (p=0.007) distributions for the glutamate-cysteine ligase catalytic subunit -3506A/G polymorphism.
Conclusions: Our study reveals the first data about the myeloperoxidase -463G/A and glutamate-cysteine ligase catalytic subunit -3506A/G gene polymorphisms for type 2 diabetes and we believe that this work will play a pioneering role for further studies.
Uvod: Fiziopatologiju diabetes mellitusa može pratiti oksida- trvni stres. Katalitičke podjedinice mijeloperoksidaze i gluta- mat-cistein ligaze su dve važne supstance koje su povezane sa održavanjem redoks ravnoteže u telu. U ovoj studiji, ispi- tivana je veza između dijabetesa, n'rvoa lipida i genskih poli- morfizama -463G/A mijeloperoksidaze i -3506A/G katali- tičke podjedinice glutamat-cistein ligaze.
Metode: Učestalost genotipova i alela određena je pomoću tehnika PCR-RFLP kod 90 pacijenata sa dijabetesom tipa 2 i 70 zdravih kontrolnih subjekata.
Rezultati: Otkrili smo povezanost između distribucija ge- notipa (p=0,023) i distribucija alela (p=0,009) -463 G/A mijeloperoksidaze u proučavanim grupama. Pored toga, postoji značajna razlika za svaku od distribucija genotipova (р=0,014) i alela (p=0,007) za polimorfizam katalitičke podjedinice -3506A/G glutamat-cistein ligaze.
Zaključak: ^laša studija otkriva prve podatke o genskim poli- morfizmima -463G/A mijebperoksidaze i -3506A/G katali- tičke podjedinice glutamat-cistein ligaze za dijabetes tipa 2 i verujemo da će ovaj rad imati pionirsku ulogu za buduće studije.</description><identifier>ISSN: 1452-8258</identifier><identifier>EISSN: 1452-8266</identifier><identifier>DOI: 10.2478/jomb-2013-0022</identifier><language>eng</language><publisher>Belgrade: Versita</publisher><subject>antioksi- dant ; antioxidant ; diabetes ; dijabetes ; oksidant ; oxidant ; polimorfizam ; polymorphism ; SNP</subject><ispartof>Journal of medical biochemistry, 2013-04, Vol.33 (2), p.156-161</ispartof><rights>Copyright Versita May 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2056-491b7c67181cea259d6a4a5267675b1c8801c09d72a88cea8d72fe352c0333de3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Eksi, Yunus Emre</creatorcontrib><creatorcontrib>Karaali, Zeynep Ermig</creatorcontrib><creatorcontrib>Incekara, Kutiuhan</creatorcontrib><creatorcontrib>Ergen, H. Arzu</creatorcontrib><title>MYELOPEROXIDASE AND GLUTAMATE-CYSTEINE LIGASE POLYMORPHISMS IN TYPE 2 DIABETES MELLITUS: A PRELIMINARY STUDY / POLIMORFIZMI MIJELOPEROKSIDAZE I GLUTAMAT-CISTEIN LIGAZE U DIABETES MELLITUSU TIPA 2: PRELIMINARNA STUDIJA</title><title>Journal of medical biochemistry</title><description>Background: Oxidative stress can accompany the physio- pathology of diabetes mellitus. Myelopercecidase and gluta- mate-cysteine ligase catalytic subunit are two important sub- stances which are connected with the maintaining of the redox balance in the body. In this study, the association be- tween diabetes, lipid levels, myeloperoxidase -463G/A, and the glutamate-cysteine ligase catalytic subunit -3506A/G gene polymorphisms have been investigated.
Methods: Frequencies of genotypes and alleles have been assessed using PCR-RFLP techniques in 90 type 2 diabetic patients and 70 healthy controls. Results: We found an association between myeloperoxidase -463 G/A genotype distributions (p=0.023) and allele distri- butions (p=0.009) in the study groups. In addition, there is a significant difference for each of the genotype (p=0.014) and allele (p=0.007) distributions for the glutamate-cysteine ligase catalytic subunit -3506A/G polymorphism.
Conclusions: Our study reveals the first data about the myeloperoxidase -463G/A and glutamate-cysteine ligase catalytic subunit -3506A/G gene polymorphisms for type 2 diabetes and we believe that this work will play a pioneering role for further studies.
Uvod: Fiziopatologiju diabetes mellitusa može pratiti oksida- trvni stres. Katalitičke podjedinice mijeloperoksidaze i gluta- mat-cistein ligaze su dve važne supstance koje su povezane sa održavanjem redoks ravnoteže u telu. U ovoj studiji, ispi- tivana je veza između dijabetesa, n'rvoa lipida i genskih poli- morfizama -463G/A mijeloperoksidaze i -3506A/G katali- tičke podjedinice glutamat-cistein ligaze.
Metode: Učestalost genotipova i alela određena je pomoću tehnika PCR-RFLP kod 90 pacijenata sa dijabetesom tipa 2 i 70 zdravih kontrolnih subjekata.
Rezultati: Otkrili smo povezanost između distribucija ge- notipa (p=0,023) i distribucija alela (p=0,009) -463 G/A mijeloperoksidaze u proučavanim grupama. Pored toga, postoji značajna razlika za svaku od distribucija genotipova (р=0,014) i alela (p=0,007) za polimorfizam katalitičke podjedinice -3506A/G glutamat-cistein ligaze.
Zaključak: ^laša studija otkriva prve podatke o genskim poli- morfizmima -463G/A mijebperoksidaze i -3506A/G katali- tičke podjedinice glutamat-cistein ligaze za dijabetes tipa 2 i verujemo da će ovaj rad imati pionirsku ulogu za buduće studije.</description><subject>antioksi- dant</subject><subject>antioxidant</subject><subject>diabetes</subject><subject>dijabetes</subject><subject>oksidant</subject><subject>oxidant</subject><subject>polimorfizam</subject><subject>polymorphism</subject><subject>SNP</subject><issn>1452-8258</issn><issn>1452-8266</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkUtP20AUhS3USlDKlvVIrE3m4fGMo26myRAuHT8UjyWcjeU4TtUImtQmqvip_TcdJwghweoe6Z5zvsXxvEuCr2kg5GizfVz6FBPmY0zpiXdGAk59ScPw06vm8tT70vcbjLkkkTjz_sWlNmmm5-k9TFWukUqmaGYKq2JltT8pc6sh0cjAbPhmqSnjdJ7dQh7nCBJky0wjiqagvmurcxRrY8AW-RgplM21gRgSNS9RbotpiUZDAbiCG1jEgGK4e4H_yB19oRG8sv0JHNAHsvsU7xkFspApRMdvSIk6oOBOffU-r-uHvr14uedecaPt5NY36QwmyvgNxTz0g4gsRRMKIknT1pRHq7AOak5DEQq-JI2UmDQ4WglaS-kc0ql1yzhtMGNs1bJz7-rYu-u2f_Zt_1Rttvvut0NWJIhYQAUWzLmuj66m2_Z9166rXffrse6eK4KrYb5qmK8a5quG-Vzg2zHwt354artV-7PbPzvxpv3jIKOEh-w_XEqRoQ</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Eksi, Yunus Emre</creator><creator>Karaali, Zeynep Ermig</creator><creator>Incekara, Kutiuhan</creator><creator>Ergen, H. 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Arzu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2056-491b7c67181cea259d6a4a5267675b1c8801c09d72a88cea8d72fe352c0333de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>antioksi- dant</topic><topic>antioxidant</topic><topic>diabetes</topic><topic>dijabetes</topic><topic>oksidant</topic><topic>oxidant</topic><topic>polimorfizam</topic><topic>polymorphism</topic><topic>SNP</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eksi, Yunus Emre</creatorcontrib><creatorcontrib>Karaali, Zeynep Ermig</creatorcontrib><creatorcontrib>Incekara, Kutiuhan</creatorcontrib><creatorcontrib>Ergen, H. Arzu</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><jtitle>Journal of medical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eksi, Yunus Emre</au><au>Karaali, Zeynep Ermig</au><au>Incekara, Kutiuhan</au><au>Ergen, H. Arzu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MYELOPEROXIDASE AND GLUTAMATE-CYSTEINE LIGASE POLYMORPHISMS IN TYPE 2 DIABETES MELLITUS: A PRELIMINARY STUDY / POLIMORFIZMI MIJELOPEROKSIDAZE I GLUTAMAT-CISTEIN LIGAZE U DIABETES MELLITUSU TIPA 2: PRELIMINARNA STUDIJA</atitle><jtitle>Journal of medical biochemistry</jtitle><date>2013-04-01</date><risdate>2013</risdate><volume>33</volume><issue>2</issue><spage>156</spage><epage>161</epage><pages>156-161</pages><issn>1452-8258</issn><eissn>1452-8266</eissn><abstract>Background: Oxidative stress can accompany the physio- pathology of diabetes mellitus. Myelopercecidase and gluta- mate-cysteine ligase catalytic subunit are two important sub- stances which are connected with the maintaining of the redox balance in the body. In this study, the association be- tween diabetes, lipid levels, myeloperoxidase -463G/A, and the glutamate-cysteine ligase catalytic subunit -3506A/G gene polymorphisms have been investigated.
Methods: Frequencies of genotypes and alleles have been assessed using PCR-RFLP techniques in 90 type 2 diabetic patients and 70 healthy controls. Results: We found an association between myeloperoxidase -463 G/A genotype distributions (p=0.023) and allele distri- butions (p=0.009) in the study groups. In addition, there is a significant difference for each of the genotype (p=0.014) and allele (p=0.007) distributions for the glutamate-cysteine ligase catalytic subunit -3506A/G polymorphism.
Conclusions: Our study reveals the first data about the myeloperoxidase -463G/A and glutamate-cysteine ligase catalytic subunit -3506A/G gene polymorphisms for type 2 diabetes and we believe that this work will play a pioneering role for further studies.
Uvod: Fiziopatologiju diabetes mellitusa može pratiti oksida- trvni stres. Katalitičke podjedinice mijeloperoksidaze i gluta- mat-cistein ligaze su dve važne supstance koje su povezane sa održavanjem redoks ravnoteže u telu. U ovoj studiji, ispi- tivana je veza između dijabetesa, n'rvoa lipida i genskih poli- morfizama -463G/A mijeloperoksidaze i -3506A/G katali- tičke podjedinice glutamat-cistein ligaze.
Metode: Učestalost genotipova i alela određena je pomoću tehnika PCR-RFLP kod 90 pacijenata sa dijabetesom tipa 2 i 70 zdravih kontrolnih subjekata.
Rezultati: Otkrili smo povezanost između distribucija ge- notipa (p=0,023) i distribucija alela (p=0,009) -463 G/A mijeloperoksidaze u proučavanim grupama. Pored toga, postoji značajna razlika za svaku od distribucija genotipova (р=0,014) i alela (p=0,007) za polimorfizam katalitičke podjedinice -3506A/G glutamat-cistein ligaze.
Zaključak: ^laša studija otkriva prve podatke o genskim poli- morfizmima -463G/A mijebperoksidaze i -3506A/G katali- tičke podjedinice glutamat-cistein ligaze za dijabetes tipa 2 i verujemo da će ovaj rad imati pionirsku ulogu za buduće studije.</abstract><cop>Belgrade</cop><pub>Versita</pub><doi>10.2478/jomb-2013-0022</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | antioksi- dant antioxidant diabetes dijabetes oksidant oxidant polimorfizam polymorphism SNP |
| title | MYELOPEROXIDASE AND GLUTAMATE-CYSTEINE LIGASE POLYMORPHISMS IN TYPE 2 DIABETES MELLITUS: A PRELIMINARY STUDY / POLIMORFIZMI MIJELOPEROKSIDAZE I GLUTAMAT-CISTEIN LIGAZE U DIABETES MELLITUSU TIPA 2: PRELIMINARNA STUDIJA |
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