Prednisolone induces osteoporosis-like phenotype in regenerating zebrafish scales

Summary We demonstrate that glucocorticoids induce an osteoporotic phenotype in regenerating scales of zebrafish. Exposure to prednisolone results in altered mineral content, enhanced matrix breakdown, and an osteoporotic gene-expression profile in osteoblasts and osteoclasts. This highlights that t...

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Veröffentlicht in:	Osteoporosis international 2014-02, Vol.25 (2), p.567-578
Hauptverfasser:	de Vrieze, E., van Kessel, M. A. H. J., Peters, H. M., Spanings, F. A. T., Flik, G., Metz, J. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Structures - drug effects Animal Structures - physiology Animals Bone Density - drug effects Disease Models, Animal Endocrinology Fish Gene Expression Profiling - methods Gene Expression Regulation - drug effects Glucocorticoids - toxicity Male Medical research Medicine Medicine & Public Health Original Article Orthopedics Osteoclasts - drug effects Osteoporosis Osteoporosis - chemically induced Osteoporosis - physiopathology Phenotype Prednisolone - analogs & derivatives Prednisolone - toxicity Regeneration Rheumatology Zebrafish
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