Cystinuria: mechanisms and management

Cystinuria is a relatively uncommon cause of pediatric stone disease, but has significant morbidity if not properly controlled because of its significant stone recurrence rate. Cystinuria is caused by the inability of the renal tubules to reabsorb filtered cystine, which is poorly soluble at a typic...

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Veröffentlicht in:	Pediatric nephrology (Berlin, West) West), 2012-11, Vol.27 (11), p.2031-2038
Hauptverfasser:	Claes, Donna J., Jackson, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Amino acids Aminoaciduria, Renal Animals Care and treatment Classification Compliance Complications and side effects Cystine - chemistry Cystine - metabolism Cystinuria - diagnosis Cystinuria - etiology Cystinuria - genetics Cystinuria - physiopathology Cystinuria - therapy Cystinuria - urine Diagnosis Diet, Protein-Restricted Diet, Sodium-Restricted Disease prevention Genetic Predisposition to Disease Humans Hydrogen-Ion Concentration Kidney Tubules - metabolism Kidney Tubules - physiopathology Medicine Medicine & Public Health Nephrolithiasis - diagnosis Nephrolithiasis - etiology Nephrolithiasis - genetics Nephrolithiasis - physiopathology Nephrolithiasis - therapy Nephrolithiasis - urine Nephrology Patient Compliance Patient outcomes Pediatrics Phenotype Physiology Potassium Citrate - therapeutic use Proteins Review Risk factors Sodium Bicarbonate - therapeutic use Solubility Sulfhydryl Compounds - therapeutic use Treatment Outcome Urine Urologic Surgical Procedures Urology
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Beschreibung
Zusammenfassung:	Cystinuria is a relatively uncommon cause of pediatric stone disease, but has significant morbidity if not properly controlled because of its significant stone recurrence rate. Cystinuria is caused by the inability of the renal tubules to reabsorb filtered cystine, which is poorly soluble at a typical urine pH
ISSN:	0931-041X 1432-198X
DOI:	10.1007/s00467-011-2092-6