Formal anti-Markovnikov Hydroamination of Terminal Aryl Alkynes with Pinacolborane and Hydroxylamines via Zr/Cu Sequential Catalysis

Formal anti-Markovnikov Hydroamination of Terminal Aryl Alkynes with Pinacolborane and Hydroxylamines via Zr/Cu Sequential Catalysis

We have developed sequential Zr/Cu catalysis involving regioselective hydroboration and electrophilic amination for the formal anti-Markovnikov hydroamination of terminal aryl alkynes. The reaction system can provide a facile access to enamines from terminal acetylenes with high regioselectivity und...

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Veröffentlicht in:Chemistry letters 2013-10, Vol.42 (10), p.1128-1130
Hauptverfasser: Sakae, Ryosuke, Hirano, Koji, Satoh, Tetsuya, Miura, Masahiro
Format: Artikel
Sprache:eng
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Zusammenfassung:We have developed sequential Zr/Cu catalysis involving regioselective hydroboration and electrophilic amination for the formal anti-Markovnikov hydroamination of terminal aryl alkynes. The reaction system can provide a facile access to enamines from terminal acetylenes with high regioselectivity under mild conditions.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.130485