Isolation and Characterization of an Anti-Insect [beta]-Toxin from the Venom of the Scorpion Isometrus maculatus

Isolation and Characterization of an Anti-Insect [beta]-Toxin from the Venom of the Scorpion Isometrus maculatus

Im-3 was isolated from the venom of the scorpion Isometrus maculatus through several steps of HPLC fractionation based on the insect paralytic activity. Injecting Im-3 into crickets induced paralysis, but no toxicity was apparent in mice after an intracerebroventricular injection. Im-3 shares sequen...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2013-01, Vol.77 (1), p.205
Hauptverfasser: KAWACHI, Tomoyuki, MIYASHITA, Masahiro, NAKAGAWA, Yoshiaki, MIYAGAWA, Hisashi
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creator KAWACHI, Tomoyuki
MIYASHITA, Masahiro
NAKAGAWA, Yoshiaki
MIYAGAWA, Hisashi
description Im-3 was isolated from the venom of the scorpion Isometrus maculatus through several steps of HPLC fractionation based on the insect paralytic activity. Injecting Im-3 into crickets induced paralysis, but no toxicity was apparent in mice after an intracerebroventricular injection. Im-3 shares sequence similarity to scorpion β-toxins that specifically affect insect sodium channels.
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source J-STAGE Free; Oxford University Press Journals All Titles (1996-Current); Open Access Titles of Japan; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry
title Isolation and Characterization of an Anti-Insect [beta]-Toxin from the Venom of the Scorpion Isometrus maculatus
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