Isolation and Characterization of an Anti-Insect [beta]-Toxin from the Venom of the Scorpion Isometrus maculatus

Isolation and Characterization of an Anti-Insect [beta]-Toxin from the Venom of the Scorpion Isometrus maculatus

Im-3 was isolated from the venom of the scorpion Isometrus maculatus through several steps of HPLC fractionation based on the insect paralytic activity. Injecting Im-3 into crickets induced paralysis, but no toxicity was apparent in mice after an intracerebroventricular injection. Im-3 shares sequen...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2013-01, Vol.77 (1), p.205
Hauptverfasser: KAWACHI, Tomoyuki, MIYASHITA, Masahiro, NAKAGAWA, Yoshiaki, MIYAGAWA, Hisashi
Format: Artikel
Sprache:eng
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Zusammenfassung:Im-3 was isolated from the venom of the scorpion Isometrus maculatus through several steps of HPLC fractionation based on the insect paralytic activity. Injecting Im-3 into crickets induced paralysis, but no toxicity was apparent in mice after an intracerebroventricular injection. Im-3 shares sequence similarity to scorpion β-toxins that specifically affect insect sodium channels.
ISSN:0916-8451
1347-6947