Some Cytotoxic Agents from the Cross Aldol Condensations of Isophorone

Some Cytotoxic Agents from the Cross Aldol Condensations of Isophorone

Cross aldol reaction of isophorone (1) with several substituted benzaldehydes was attempted. Some mild reaction conditions gave a hydroxylated addition compound (9) as the intermediate. Some of the dehydrated products showed the growth inhibitory effect against L-1210. Furthermore, 3-oxygenated isop...

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Veröffentlicht in:Nippon Kagakukai shi (1972) 1995-09, Vol.1995 (9), p.718-723
Hauptverfasser: TAKE, Masa-aki, ISHIMI, Katsuhiro, SAKATA, Takako, MAKINO, Mitsuko, FUJIMOTO, Yasuo, TAKAGI, Yuzuru, ICHINOHE, Yoshiyuki
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Sprache:eng
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Zusammenfassung:Cross aldol reaction of isophorone (1) with several substituted benzaldehydes was attempted. Some mild reaction conditions gave a hydroxylated addition compound (9) as the intermediate. Some of the dehydrated products showed the growth inhibitory effect against L-1210. Furthermore, 3-oxygenated isophorone derivative (10) was obtained by the oxidation of 1 with Fieser's reagent.
ISSN:0369-4577
2185-0925
DOI:10.1246/nikkashi.1995.718