A ONE-MONTH REPEATED ORAL DOSE TOXICITY STUDY OF METHOTREXATE IN UNILATERALLY NEPHRECTOMIZED RATS

A repeated oral dose toxicity study of methotrexate(MTX)was conducted in order to examine whether the enhancement of MTX toxicity would occur in unilaterally nephrectomized(UNX)rats. UNX rats or sham-treated(SHAM)rats received dosages of 0, 0.06, 0.2 or 0.6 mg/kg/day(control animals received physiol...

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Veröffentlicht in:Journal of toxicological sciences 1998/11/26, Vol.23(SupplementV), pp.681-699
Hauptverfasser: MURAKAMI, Yoshinori, YAMAZAKI, Kiyomi, SAKAUCHI, Narumi, OGASAWARA, Hiroyuki, YAMASHITA, Noriaki, MASUDA, Tatsuki, TAUCHI, Kiyonori
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