EFFECTS ON OFFSPRING INDUCED BY ORAL ADMINISTRATION OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE TO THE FEMALE RATS IN PERI-AND POST-NATAL PERIODS

A perinatal and postnatal study was carried out in Slc : SD rats orally administered Hydroxypropylmethylcellulose acetate succinate (HPMCAS), a useful pharmaceutical excipient, at dose levels of 625, 1, 250 and 2, 500 mg/kg/day for a period from day 17 of gestation to day 21 after delivery. All pregnant rats were allowed to litter naturally, and the postnatal develop-ment of the offsprings was observed. In the administered group of 2, 500 mg/kg, the liver weight was significantly increased in males and showed a tendency to increase in females as compared with control. No significant differences between the control group and the administered groups were found in postnatal growth and differentiation, behavior and reproductive ability of male and female offsprings.