TERATOLOGICAL STUDY OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN RABBITS

A teratogical study was carried out in New Zealand White rabbits in order to examine the teratogenic potentiality of HPMCAS, a useful pharmaceutical excipient. HPMCAS was orally administered at dose levels of 625, 1, 250 and 2, 500 mg/kg/day for a period of 13 days from day 6 to day 18 of gestation....

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Veröffentlicht in:	Journal of toxicological sciences 1985/10/31, Vol.10(SupplementII), pp.227-234
Hauptverfasser:	HOSHI, Noboru, UENO, Koichi, IGARASHI, Takashi, KITAGAWA, Haruo, FUJITA, Teruko, ICHIKAWA, Nobuo, KONDO, Yuko, ISODA, Masae
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced Administration, Oral Animals Biological and medical sciences Body Weight - drug effects Bone and Bones - abnormalities Drinking - drug effects Drug toxicity and drugs side effects treatment Eating - drug effects Female Fetus - drug effects Medical sciences Methylcellulose - administration & dosage Methylcellulose - analogs & derivatives Methylcellulose - toxicity Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Pregnancy rabbit Rabbits
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Zusammenfassung:	A teratogical study was carried out in New Zealand White rabbits in order to examine the teratogenic potentiality of HPMCAS, a useful pharmaceutical excipient. HPMCAS was orally administered at dose levels of 625, 1, 250 and 2, 500 mg/kg/day for a period of 13 days from day 6 to day 18 of gestation. All pregnant females were sacrificed on day 29 of gestation and their fetuses were examined. The administration of HPMCAS during a period of organogenesis produced no embryotoxic and teratogenic effects as well as no influence on behavior, appearance and growth of animals.
ISSN:	0388-1350 1880-3989
DOI:	10.2131/jts.10.SupplementII_227