Spontaneous Tumors in p53-Deficient Mice

The p53-deficient mice (Riken mice) were examined for tumors occurring spontaneously histopathologically and hematologically. Histopathologically, 87% of the males with tumors and 86% of the females with tumors had malignant lymphomas or lymphatic hyperplasia. It must be safe to say that more marked...

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Veröffentlicht in:	Journal of Toxicologic Pathology 1997/12/30, Vol.10(4), pp.239-242
Hauptverfasser:	Okada, Masaaki, Kimura, Hitoshi, Yoshijima, Ken-ichi, Koike, Tsuneo, Imaeda, Tomoko, Tanikawa, Yutaka, Shinoda, Akihiro, Nishio, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Homozygote Malignant lymphoma p53-deficient mouse Spontaneous tumor
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The p53-deficient mice (Riken mice) were examined for tumors occurring spontaneously histopathologically and hematologically. Histopathologically, 87% of the males with tumors and 86% of the females with tumors had malignant lymphomas or lymphatic hyperplasia. It must be safe to say that more marked tendency to have spontaneous malignant lymphomas is seen in the p53-deficient mouse.
ISSN:	0914-9198 1881-915X 1347-7404
DOI:	10.1293/tox.10.239