Expression of CHD1L in bladder cancer and its influence on prognosis and survival

Chromodomain helicase/ATPase DNA-binding protein 1-like (CHD1L) is overexpressed and highly associated with poor prognosis in many malignancies. However, the role of CHD1L in bladder cancer (BC) has not been thoroughly elucidated. The aim of this study is to investigate the relationship of CHD1L exp...

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Veröffentlicht in:	Tumor biology 2013-12, Vol.34 (6), p.3687-3690
Hauptverfasser:	Tian, Feng, Xu, Feng, Zhang, Zheng-Yu, Ge, Jing-Ping, Wei, Zhi-Feng, Xu, Xiao-Feng, Cheng, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Bladder cancer Cancer Research DNA Helicases - metabolism DNA-Binding Proteins - metabolism Female Genes Humans Immunohistochemistry Kaplan-Meier Estimate Male Medical prognosis Middle Aged Multivariate Analysis Neoplasm Grading Neoplasm Staging Prognosis Research Article Survival Analysis Time Factors Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology
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Zusammenfassung:	Chromodomain helicase/ATPase DNA-binding protein 1-like (CHD1L) is overexpressed and highly associated with poor prognosis in many malignancies. However, the role of CHD1L in bladder cancer (BC) has not been thoroughly elucidated. The aim of this study is to investigate the relationship of CHD1L expression with clinicopathological parameters and prognosis in BC. Immunohistochemistry was carried out to investigate the protein expression of CHD1L in 153 BC tissues and 87 adjacent noncancerous tissues. Our data found that CHD1L protein expression was significantly higher in BC tissues than in adjacent noncancerous tissues ( P
ISSN:	1010-4283 1423-0380
DOI:	10.1007/s13277-013-0951-4