Concise Stereoselective Total Synthesis of Leiocarpin C

Concise Stereoselective Total Synthesis of Leiocarpin C

A simple and highly concise strategy has been developed for the stereoselective total synthesis of leiocarpin C starting from commercially available mandelic ester. The strategy utilizes the OsO4‐catalyzed cis‐hydroxylation and selective reduction with K‐Selectride as key steps.

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Bibliographische Detailangaben
Veröffentlicht in:Helvetica chimica acta 2013-12, Vol.96 (12), p.2179-2184
Hauptverfasser: Chandra Rao, Dasireddi, Shekhar, Vanam, Kumar Reddy, Dorigondla, Chinnababu, Baggu, Venkateswarlu, Yenamandra
Format: Artikel
Sprache:eng
Schlagworte:
Goniothalamus leiocarpus
Hydroxylation
K-Selectride
Lactones
Leiocarpin C
Pregnancy
Stereoselective synthesis
Total synthesis
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Beschreibung
Zusammenfassung:A simple and highly concise strategy has been developed for the stereoselective total synthesis of leiocarpin C starting from commercially available mandelic ester. The strategy utilizes the OsO4‐catalyzed cis‐hydroxylation and selective reduction with K‐Selectride as key steps.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201200656