Water Mediation Is Essential to Nucleation of [beta]-Turn Formation in Peptide Folding Motifs

Water Mediation Is Essential to Nucleation of [beta]-Turn Formation in Peptide Folding Motifs

Water-mediated bond formation: The structure of the peptide GPG-NH2 has been investigated in aqueous solution to understand the role of water in the formation of a [beta]-turn. Using a combination of neutron diffraction enhanced by isotopic substitution, NMR spectroscopy, and computer simulations, i...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-12, Vol.52 (49), p.13091
Hauptverfasser: Busch, Sebastian, Bruce, Chrystal D, Redfield, Christina, Lorenz, Christian D, McLain, Sylvia E
Format: Artikel
Sprache:eng
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Zusammenfassung:Water-mediated bond formation: The structure of the peptide GPG-NH2 has been investigated in aqueous solution to understand the role of water in the formation of a [beta]-turn. Using a combination of neutron diffraction enhanced by isotopic substitution, NMR spectroscopy, and computer simulations, it was found that water is an essential component to initiate folding in solution.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201307657