Palladium-catalyzed Direct Monoarylation of Thiophene-, Benzothiophene-, and Indoleacetic Acids through Regioselective C–H Bond Cleavage

Palladium-catalyzed Direct Monoarylation of Thiophene-, Benzothiophene-, and Indoleacetic Acids through Regioselective C–H Bond Cleavage

Regioselective monoarylation of thiophene-3-acetic acid with aryl bromides proceeds efficiently under palladium catalysis to selectively give the corresponding C2-arylated thiophene derivatives. The procedure is also applicable to the C2-arylations of benzothiophene-3- and indole-3-acetic acids.

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Veröffentlicht in:Chemistry letters 2011-09, Vol.40 (9), p.1015-1017
Hauptverfasser: Takeda, Daisuke, Yamashita, Mana, Hirano, Koji, Satoh, Tetsuya, Miura, Masahiro
Format: Artikel
Sprache:eng
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Zusammenfassung:Regioselective monoarylation of thiophene-3-acetic acid with aryl bromides proceeds efficiently under palladium catalysis to selectively give the corresponding C2-arylated thiophene derivatives. The procedure is also applicable to the C2-arylations of benzothiophene-3- and indole-3-acetic acids.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2011.1015