Cucurbit[7]uril Inclusion Complexes of Platinum(II)-based Anticancer Drugs

The 1H NMR characterization of the encapsulation of bisplatinum complex CT-3610 by cucurbit[7]uril is reported. The formation of the intermediate monoinclusion complex can be easily detected in the 1H NMR spectrum, and the pD dependence of the equilibrium has also been assessed. No significant differences were observed in cytotoxicity experiments between the free and encapsulated form of CT-3610 on A2780 and cisplatin resistant A2780 human ovarian cancer cell lines.