An Effective Synthesis of a (Pyridin-3-yl)isoxazole via 1,3-Dipolar Cycloaddition Using ZnCl2

An Effective Synthesis of a (Pyridin-3-yl)isoxazole via 1,3-Dipolar Cycloaddition Using ZnCl2

We described a rare example of an effective isoxazole synthesis via a 1,3-dipolar cycloaddition using ZnCl2, which allowed us to synthesize novel (2-aminopyridin-3-yl)isoxazole derivatives effectively. In addition, these compounds demonstrated potent antifungal activity in vitro against both Candida...

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Veröffentlicht in:Chemistry letters 2010-10, Vol.39 (10), p.1033
Hauptverfasser: Tanaka, Keigo, Inoue, Satoshi, Murai, Norio, Shirotori, Syuji, Nakamoto, Kazutaka, Abe, Shinya, Horii, Takaaki, Miyazaki, Mamiko, Hata, Katsura, Watanabe, Naoaki, Asada, Makoto, Matsukura, Masayuki
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Sprache:eng
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Zusammenfassung:We described a rare example of an effective isoxazole synthesis via a 1,3-dipolar cycloaddition using ZnCl2, which allowed us to synthesize novel (2-aminopyridin-3-yl)isoxazole derivatives effectively. In addition, these compounds demonstrated potent antifungal activity in vitro against both Candida albicans and Aspergillus fumigatus.
ISSN:0366-7022
1348-0715