Organocatalytic Asymmetric syn-Selective Direct Aldol Reaction in Ionic Liquid

Organocatalytic Asymmetric syn-Selective Direct Aldol Reaction in Ionic Liquid

A practical and recyclable organocatalytic strategy is developed to provide syn-selective aldol products in ionic liquid. The siloxy serine organocatalyst mediates the direct aldol reaction of TBSO-protected hydroxyacetone with a variety of aldehyde to provide the β-hydroxycarbonyl scaffolds in good...

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Veröffentlicht in:Chemistry letters 2010-05, Vol.39 (5), p.490-492
Hauptverfasser: Yong, Fui-Fong, Poh, Chai-Yun, Chua, Guan-Leong, Teo, Yong-Chua
Format: Artikel
Sprache:eng
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Zusammenfassung:A practical and recyclable organocatalytic strategy is developed to provide syn-selective aldol products in ionic liquid. The siloxy serine organocatalyst mediates the direct aldol reaction of TBSO-protected hydroxyacetone with a variety of aldehyde to provide the β-hydroxycarbonyl scaffolds in good yields and enantioselectivities up to 94%.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2010.490