Guest Binding, Cellular Uptake, and Molecular Delivery of Water-soluble Cyclophanes Having a Pyrene Moiety

Guest Binding, Cellular Uptake, and Molecular Delivery of Water-soluble Cyclophanes Having a Pyrene Moiety

Cationic water-soluble cyclophane bearing a pyrene 1 was synthesized as a host for inclusion of anionic guest molecules. Cationic host 1 was found to be incorporated into human hepatoblastome HepG2 cells effectively. Moreover, 8-anilinonaphthalene-1-sulfonate (ANS) having an inherent poor cell perme...

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Veröffentlicht in:Chemistry letters 2010-12, Vol.39 (12), p.1321-1322
Hauptverfasser: Hayashida, Osamu, Eguchi, Chika, Kimura, Keiichiro, Oyama, Yu, Nakashima, Tomomi, Shioji, Kosei
Format: Artikel
Sprache:eng
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Zusammenfassung:Cationic water-soluble cyclophane bearing a pyrene 1 was synthesized as a host for inclusion of anionic guest molecules. Cationic host 1 was found to be incorporated into human hepatoblastome HepG2 cells effectively. Moreover, 8-anilinonaphthalene-1-sulfonate (ANS) having an inherent poor cell permeability was taken up into the cells in the presence of 1 through formation of host–guest complexes.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2010.1321