Cationic Three-component Coupling Involving an Optically Active Enamine Derivative. From Time Integration to Space Integration of Reactions

Cationic Three-component Coupling Involving an Optically Active Enamine Derivative. From Time Integration to Space Integration of Reactions

Three-component coupling of an N-acyliminium cation pool, an optically active 2-t-butyloxazole derivative, and a carbon nucleophile such as allyltrimethylsilane was effectively achieved by a rapid one-pot method at −78 °C and a flow microreactor method at 0 °C.

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Veröffentlicht in:Chemistry letters 2010-04, Vol.39 (4), p.404-406
Hauptverfasser: Suga, Seiji, Yamada, Daisuke, Yoshida, Jun-ichi
Format: Artikel
Sprache:eng
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Zusammenfassung:Three-component coupling of an N-acyliminium cation pool, an optically active 2-t-butyloxazole derivative, and a carbon nucleophile such as allyltrimethylsilane was effectively achieved by a rapid one-pot method at −78 °C and a flow microreactor method at 0 °C.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2010.404