Cobalt-catalyzed Cross-coupling Reactions of Aryl Bromides with Alkyl Grignard Reagents

Cobalt-catalyzed Cross-coupling Reactions of Aryl Bromides with Alkyl Grignard Reagents

Aryl bromides react with primary alkyl Grignard reagents in the presence of N,N,N′,N′-tetramethyl-1,3-propanediamine and catalytic amounts of cobalt(II) chloride and an N-heterocyclic carbene to yield the corresponding cross-coupling products in high yields.

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Veröffentlicht in:Chemistry letters 2008-11, Vol.37 (11), p.1178-1179
Hauptverfasser: Hamaguchi, Hiroyuki, Uemura, Minoru, Yasui, Hiroto, Yorimitsu, Hideki, Oshima, Koichiro
Format: Artikel
Sprache:eng
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Zusammenfassung:Aryl bromides react with primary alkyl Grignard reagents in the presence of N,N,N′,N′-tetramethyl-1,3-propanediamine and catalytic amounts of cobalt(II) chloride and an N-heterocyclic carbene to yield the corresponding cross-coupling products in high yields.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2008.1178