Synthesis and Stereochemical Assignment of Angucycline Antibiotic, PD-116740
The first total synthesis and absolute structure assignment of PD-116740 (2) was achieved by exploiting two key steps: 1) a thermal ring expansion of a benzocyclobutene derivative, and 2) pinacol cyclization of biaryl dialdehyde.
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Veröffentlicht in: | Chemistry letters 2008-04, Vol.37 (4), p.470-471 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | The first total synthesis and absolute structure assignment of PD-116740 (2) was achieved by exploiting two key steps: 1) a thermal ring expansion of a benzocyclobutene derivative, and 2) pinacol cyclization of biaryl dialdehyde. |
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ISSN: | 0366-7022 1348-0715 |
DOI: | 10.1246/cl.2008.470 |