Chiral Scandium-catalyzed Highly Stereoselective Ring-opening of meso-Epoxides with Thiols
The desymmetrization of meso-epoxides with thiols proceeded smoothly in dichloromethane or dichloroethane in the presence of a catalytic amount of a chiral scandium complex consisting of Sc(OTf)3 and chiral bipyridine 1, to afford the corresponding sulfides in high yields with high enantioselectivit...
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| Veröffentlicht in: | Chemistry letters 2007-01, Vol.36 (1), p.34-35 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The desymmetrization of meso-epoxides with thiols proceeded smoothly in dichloromethane or dichloroethane in the presence of a catalytic amount of a chiral scandium complex consisting of Sc(OTf)3 and chiral bipyridine 1, to afford the corresponding sulfides in high yields with high enantioselectivities. |
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| ISSN: | 0366-7022 1348-0715 |
| DOI: | 10.1246/cl.2007.34 |