Peptide Ligation Using a Building Block Having a Cysteinyl Prolyl Ester (CPE) Autoactivating Unit at the Carboxy Terminus

Peptide Ligation Using a Building Block Having a Cysteinyl Prolyl Ester (CPE) Autoactivating Unit at the Carboxy Terminus

CPE peptide ligation using a building block containing a cysteinyl prolyl ester (CPE) autoactivating unit is described. The peptide building block can be prepared by a standard Fmoc chemistry and used in thiol-mediated ligation, such as native chemical ligation.

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Veröffentlicht in:Chemistry letters 2007-01, Vol.36 (1), p.76-77
Hauptverfasser: Kawakami, Toru, Aimoto, Saburo
Format: Artikel
Sprache:eng
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Zusammenfassung:CPE peptide ligation using a building block containing a cysteinyl prolyl ester (CPE) autoactivating unit is described. The peptide building block can be prepared by a standard Fmoc chemistry and used in thiol-mediated ligation, such as native chemical ligation.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2007.76