N-Hydroxysuccinimide-promoted Oxidation of Primary Alcohols and Aldehydes to Form Active Esters with Hypervalent(III) Iodine

N-Hydroxysuccinimide-promoted Oxidation of Primary Alcohols and Aldehydes to Form Active Esters with Hypervalent(III) Iodine

A simple, mild, and efficient method for the conversion of primary alcohols and aldehydes to N-hydroxysuccinimide esters with (diacetoxyiodo)benzene in high yield is developed. N-Hydroxysuccinimide acts not only as an esterification partner but also as an activator of PhI(OAc)2 in this reaction.

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Veröffentlicht in:Chemistry letters 2006-06, Vol.35 (6), p.566-567
Hauptverfasser: Wang, Naiwei, Liu, Renhua, Xu, Qing, Liang, Xinmiao
Format: Artikel
Sprache:eng
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Zusammenfassung:A simple, mild, and efficient method for the conversion of primary alcohols and aldehydes to N-hydroxysuccinimide esters with (diacetoxyiodo)benzene in high yield is developed. N-Hydroxysuccinimide acts not only as an esterification partner but also as an activator of PhI(OAc)2 in this reaction.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2006.566