Efficient Method for the Lactonization of [omega]-Hydroxycarboxylic Acids with Di-2-thienyl Carbonate by the Promotion of Catalytic Amounts of DMAP and Hf(OTf)4

Efficient Method for the Lactonization of [omega]-Hydroxycarboxylic Acids with Di-2-thienyl Carbonate by the Promotion of Catalytic Amounts of DMAP and Hf(OTf)4

An efficient method for the synthesis of macrolides from ω-hydroxycarboxylic acids is established by using an equimolar amount of di-2-thienyl carbonate (2-DTC) and catalytic amounts of 4-(dimethylamino)pyridine (DMAP) and group 4 metal triflates such as hafnium(IV) trifluoromethanesulfonate (Hf(OTf...

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Veröffentlicht in:Chemistry letters 2005-05, Vol.34 (5), p.710
Hauptverfasser: Oohashi, Yoshiaki, Fukumoto, Kentarou, Mukaiyama, Teruaki
Format: Artikel
Sprache:eng
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Zusammenfassung:An efficient method for the synthesis of macrolides from ω-hydroxycarboxylic acids is established by using an equimolar amount of di-2-thienyl carbonate (2-DTC) and catalytic amounts of 4-(dimethylamino)pyridine (DMAP) and group 4 metal triflates such as hafnium(IV) trifluoromethanesulfonate (Hf(OTf)4).
ISSN:0366-7022
1348-0715