A New Method for the Lactonization of [omega]-Hydroxy Carboxylic Acids with Di-2-thienyl Carbonate by the Promotion of DMAP and Iodine

A New Method for the Lactonization of [omega]-Hydroxy Carboxylic Acids with Di-2-thienyl Carbonate by the Promotion of DMAP and Iodine

Successive reactions of ω-hydroxycarboxylic acids with an equimolar amount of di-2-thienyl carbonate (2-DTC) in the presence of a catalytic amount of 4-(dimethylamino)pyridine (DMAP) followed by an addition of 2-4 equimolar amounts of iodine afforded the corresponding lactones in good to high yields...

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Veröffentlicht in:Chemistry letters 2005-01, Vol.34 (1), p.72
Hauptverfasser: Oohashi, Yoshiaki, Fukumoto, Kentarou, Mukaiyama, Teruaki
Format: Artikel
Sprache:eng
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Zusammenfassung:Successive reactions of ω-hydroxycarboxylic acids with an equimolar amount of di-2-thienyl carbonate (2-DTC) in the presence of a catalytic amount of 4-(dimethylamino)pyridine (DMAP) followed by an addition of 2-4 equimolar amounts of iodine afforded the corresponding lactones in good to high yields.
ISSN:0366-7022
1348-0715