One-pot Synthesis of Substituted Quinolines by Iridium-catalyzed Three-component Coupling Reaction

A convenient and efficient synthesis of substituted quinolines in a simple one-pot reaction of an arylamine 1, an aromatic aldehyde or aliphatic aldehyde 2 and an aliphatic aldehyde 3 in the presence of transition metal complexes or Lewis acids was developed. Among them, the iridium catalyst [Ir(cod)Cl]2 catalyzed the reaction most efficiently.