A Synthesis of AB-Ring Model System of Taxane Framework by Way of Intramolecular Knoevenagel Cyclization

A Synthesis of AB-Ring Model System of Taxane Framework by Way of Intramolecular Knoevenagel Cyclization

Methyl 1,2-dialkoxy-11,11-dimethyl-9-oxobicyclo[5.3.1]-undec-7-en-8-carboxylate 19 was synthesized by cesium fluoride-mediated intramolecular Knoevenagel reaction of methyl 4-(1,8-dialkoxy-2,2-dimethyl-3-oxocyclooctyl)-3-oxobutanonate 18.

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Veröffentlicht in:Chemistry letters 2002-01, Vol.31 (1), p.92-93
Hauptverfasser: Arai, Hidehiro, Ohno, Ayako, Tani, Yu-ichirou, Imachi, Shouhei, Mukaiyama, Teruaki
Format: Artikel
Sprache:eng
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Zusammenfassung:Methyl 1,2-dialkoxy-11,11-dimethyl-9-oxobicyclo[5.3.1]-undec-7-en-8-carboxylate 19 was synthesized by cesium fluoride-mediated intramolecular Knoevenagel reaction of methyl 4-(1,8-dialkoxy-2,2-dimethyl-3-oxocyclooctyl)-3-oxobutanonate 18.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2002.92