Pd(en) as a Sequence-Selective Molecular Pinch for [alpha]-Helical Peptides

Pd(en) as a Sequence-Selective Molecular Pinch for [alpha]-Helical Peptides

A palladium(II)(ethylenediamine) complex was found to selectively stabilize α-helix conformation of peptides having two histidine (His) residues at i and i + (3 or 4) positions, whereas the helix conformation of the other peptides having one or two His at different positions is destabilized.

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Veröffentlicht in:Chemistry letters 2001-01, Vol.30 (1), p.16
Hauptverfasser: Hamachi, Itaru, Kasagi, Noriyuki, Kiyonaka, Shigeki, Nagase, Tsuyoshi, Mito-oka, Yasuko, Shinkai, Seiji
Format: Artikel
Sprache:eng
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Zusammenfassung:A palladium(II)(ethylenediamine) complex was found to selectively stabilize α-helix conformation of peptides having two histidine (His) residues at i and i + (3 or 4) positions, whereas the helix conformation of the other peptides having one or two His at different positions is destabilized.
ISSN:0366-7022
1348-0715