The First Total Synthesis of (−)-Benzomalvin A via Intramolecular Aza-Wittig Reactions

The First Total Synthesis of (−)-Benzomalvin A via Intramolecular Aza-Wittig Reactions

The first total synthesis of (−)-benzomalvin A 1, which possesses quinazolin-4(3H)-one moiety and 1,4-benzodiazepin-5-one moiety, was described. Both of 6- and 7-membered ring skeletons were efficiently constructed by intramolecular aza-Wittig reactions as the key reactions.

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Veröffentlicht in:Chemistry letters 1997-09, Vol.26 (9), p.869-870
Hauptverfasser: Sugimori, Toshiyuki, Okawa, Tomohiro, Eguchi, Shoji, Yashima, Eiji, Okamoto, Yoshio
Format: Artikel
Sprache:eng
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Zusammenfassung:The first total synthesis of (−)-benzomalvin A 1, which possesses quinazolin-4(3H)-one moiety and 1,4-benzodiazepin-5-one moiety, was described. Both of 6- and 7-membered ring skeletons were efficiently constructed by intramolecular aza-Wittig reactions as the key reactions.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.1997.869