Titanocene Induced Deoxygenation of Di-epoxides - A Convenient Regioselective Preparation of 1,3-Diols

Titanocene induced regioselective opening of 2,4-di-epoxy alcohols to 1-ene-3,5-diols is described. Diepoxy alcohols were treated with 3 eq. of Cp2TiCl in dry THF to obtain 1-ene-3,5 diols with conservation of stereochemistry at C-3 and C-5 was observed.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemistry letters 1997-09, Vol.26 (9), p.905-906
Hauptverfasser:	Yadav, J. S, Srinivas, Dale
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Titanocene induced regioselective opening of 2,4-di-epoxy alcohols to 1-ene-3,5-diols is described. Diepoxy alcohols were treated with 3 eq. of Cp2TiCl in dry THF to obtain 1-ene-3,5 diols with conservation of stereochemistry at C-3 and C-5 was observed.
ISSN:	0366-7022 1348-0715
DOI:	10.1246/cl.1997.905