Syntheses and Doxorubicin-Inclusion Abilities of [beta]-Cyclodextrin Derivatives with a Hydroquinone [alpha]-Glycoside Residue Attached at the Primary Side

This paper describes syntheses and doxorubicin-inclusion abilities of β-cyclodextrin (CyD) derivatives with a hydroquinone α-glycoside residue attached at the primary side. The hydroquinone glycoside having an α-D-glucosidic or 2-acetamido-2-deoxy-α-D-glucosidic linkage became a useful component for providing an α-D-glucose- or 2-acetamido-2-deoxy-α-D-glucose-β-CyD conjugate. The surface plasmon resonance analyses of these β-CyD derivatives for the anticancer agent, doxorubicin, indicated that they had excellent inclusion associations on the order of 105 m-1 for the immobilized doxorubicin.