Synthesis of Some New Spiropyranoquinolines and Evaluation of Their Free Radical Scavenging Activity
The preparation of some new spiro-substituted 4-hydroxypyranoquinolinones and their corresponding dihydropyrano cis-diols is described. The free radical scavenging activity of the compounds was determined by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH)...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2009/05/01, Vol.57(5), pp.446-452 |
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| container_end_page | 452 |
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| container_issue | 5 |
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| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 57 |
| creator | Panteleon, Vassiliki Kostakis, Ioannis K. Marakos, Panagiotis Pouli, Nicole Andreadou, Ioanna |
| description | The preparation of some new spiro-substituted 4-hydroxypyranoquinolinones and their corresponding dihydropyrano cis-diols is described. The free radical scavenging activity of the compounds was determined by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the superoxide anions generated by the enzymic xanthine–xanthine oxidase system. The spiroadamatylpyranoquinolinone analogue proved to be the most efficient free radical scavenger. |
| doi_str_mv | 10.1248/cpb.57.446 |
| format | Article |
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The free radical scavenging activity of the compounds was determined by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the superoxide anions generated by the enzymic xanthine–xanthine oxidase system. 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Pharm. Bull.</addtitle><description>The preparation of some new spiro-substituted 4-hydroxypyranoquinolinones and their corresponding dihydropyrano cis-diols is described. The free radical scavenging activity of the compounds was determined by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the superoxide anions generated by the enzymic xanthine–xanthine oxidase system. The spiroadamatylpyranoquinolinone analogue proved to be the most efficient free radical scavenger.</description><subject>Alanine - analogs & derivatives</subject><subject>Alanine - chemistry</subject><subject>antioxidant activity</subject><subject>Biphenyl Compounds - chemistry</subject><subject>Cinnamates - chemistry</subject><subject>Free Radical Scavengers - chemical synthesis</subject><subject>Free Radical Scavengers - chemistry</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Free Radicals - chemistry</subject><subject>Inhibitory Concentration 50</subject><subject>Molecular Structure</subject><subject>Picrates - chemistry</subject><subject>Pyrans - chemical synthesis</subject><subject>Pyrans - chemistry</subject><subject>Pyrans - pharmacology</subject><subject>quinoline</subject><subject>Quinolines - chemical synthesis</subject><subject>Quinolines - chemistry</subject><subject>Quinolines - pharmacology</subject><subject>Quinolones - chemistry</subject><subject>radical scavenging activity</subject><subject>Spiro Compounds - chemical synthesis</subject><subject>Spiro Compounds - chemistry</subject><subject>Spiro Compounds - pharmacology</subject><subject>spiropyranoquinoline</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEQhoMotn5c_AES8CZszedme5JS6geIgtVzSLOzbco2uybbSv-9Ka16yRzyzDMzL0JXlAwoE8WdbWcDqQZC5EeoT7lQmWSMH6M-IWSYMZ7zHjqLcUkIk0TxU9SjQ8GIUryPyunWdwuILuKmwtNmBfgVvvG0daFpt8H45mvtfFM7DxEbX-LJxtRr07nG7xo-FuACfggA-N2UzpoaT63ZgJ87P8cj27mN67YX6KQydYTLQz1Hnw-Tj_FT9vL2-DwevWRWKNplVLKcK1uQQirBbDUjQoAsqRLCimEpOSlEwQo7E8bInFTclkSVtkgHgsyt5OfoZu9tQ1obYqeXzTr4NFJTkRPBcsJ4om73lA1NjAEq3Qa3MmGrKdG7QHUKVEulU6AJvj4o17MVlP_oIcEE3O-BZezMHP4AEzpna_h1yf2TlP8_CxM0eP4D7lCHbg</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Panteleon, Vassiliki</creator><creator>Kostakis, Ioannis K.</creator><creator>Marakos, Panagiotis</creator><creator>Pouli, Nicole</creator><creator>Andreadou, Ioanna</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20090501</creationdate><title>Synthesis of Some New Spiropyranoquinolines and Evaluation of Their Free Radical Scavenging Activity</title><author>Panteleon, Vassiliki ; 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Pharm. Bull.</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>57</volume><issue>5</issue><spage>446</spage><epage>452</epage><pages>446-452</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>The preparation of some new spiro-substituted 4-hydroxypyranoquinolinones and their corresponding dihydropyrano cis-diols is described. The free radical scavenging activity of the compounds was determined by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the superoxide anions generated by the enzymic xanthine–xanthine oxidase system. The spiroadamatylpyranoquinolinone analogue proved to be the most efficient free radical scavenger.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>19420773</pmid><doi>10.1248/cpb.57.446</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 2009/05/01, Vol.57(5), pp.446-452 |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Alanine - analogs & derivatives Alanine - chemistry antioxidant activity Biphenyl Compounds - chemistry Cinnamates - chemistry Free Radical Scavengers - chemical synthesis Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Free Radicals - chemistry Inhibitory Concentration 50 Molecular Structure Picrates - chemistry Pyrans - chemical synthesis Pyrans - chemistry Pyrans - pharmacology quinoline Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacology Quinolones - chemistry radical scavenging activity Spiro Compounds - chemical synthesis Spiro Compounds - chemistry Spiro Compounds - pharmacology spiropyranoquinoline |
| title | Synthesis of Some New Spiropyranoquinolines and Evaluation of Their Free Radical Scavenging Activity |
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