Synthesis of Some New Spiropyranoquinolines and Evaluation of Their Free Radical Scavenging Activity

The preparation of some new spiro-substituted 4-hydroxypyranoquinolinones and their corresponding dihydropyrano cis-diols is described. The free radical scavenging activity of the compounds was determined by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH)...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2009/05/01, Vol.57(5), pp.446-452
Hauptverfasser:	Panteleon, Vassiliki, Kostakis, Ioannis K., Marakos, Panagiotis, Pouli, Nicole, Andreadou, Ioanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - analogs & derivatives Alanine - chemistry antioxidant activity Biphenyl Compounds - chemistry Cinnamates - chemistry Free Radical Scavengers - chemical synthesis Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Free Radicals - chemistry Inhibitory Concentration 50 Molecular Structure Picrates - chemistry Pyrans - chemical synthesis Pyrans - chemistry Pyrans - pharmacology quinoline Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacology Quinolones - chemistry radical scavenging activity Spiro Compounds - chemical synthesis Spiro Compounds - chemistry Spiro Compounds - pharmacology spiropyranoquinoline
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Zusammenfassung:	The preparation of some new spiro-substituted 4-hydroxypyranoquinolinones and their corresponding dihydropyrano cis-diols is described. The free radical scavenging activity of the compounds was determined by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the superoxide anions generated by the enzymic xanthine–xanthine oxidase system. The spiroadamatylpyranoquinolinone analogue proved to be the most efficient free radical scavenger.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.57.446