Synthesis of Panax Acetylenes

Synthesis of Panax Acetylenes

Acetylpanaxydol (1-Ac), PQ-3 (2) and panaxydiol (3) and their optical isomers were synthesized from L-(+)-diethyl tartrate. The absolute configurations of 1-Ac, 2 and 3 were determined to be 1-Ac (3R,9R,10S), 2 (9R,10S) and 3 (3R,10S), respectively, by comparisons of their optical rotations and the...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 2004-04, Vol.52 (4), p.418
Hauptverfasser: Satoh, Mitsuru, Watanabe, Mitsuo, Kawahata, Masatoshi, Mohri, Kunihiko, Yoshida, Yuki, Isobe, Kimiaki, Fujimoto, Yasuo
Format: Artikel
Sprache:eng
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Zusammenfassung:Acetylpanaxydol (1-Ac), PQ-3 (2) and panaxydiol (3) and their optical isomers were synthesized from L-(+)-diethyl tartrate. The absolute configurations of 1-Ac, 2 and 3 were determined to be 1-Ac (3R,9R,10S), 2 (9R,10S) and 3 (3R,10S), respectively, by comparisons of their optical rotations and the NMR data of their MTPA esters with those of natural products.
ISSN:0009-2363
1347-5223