Enzymes Inhibiting Lignans from Vitex negundo

Enzymes Inhibiting Lignans from Vitex negundo

Two new lignans trivially named negundins A (1) and B (2), were isolated along with (+)-diasyringaresinol (3), (+)-lyoniresinol (4), vitrofolal E (5) and vitrofolal F (6), reported for the first time from this species. The structures of the new compounds were established through spectral studies. Co...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 2004, Vol.52(11), pp.1269-1272
Hauptverfasser: Azhar-Ul-Haq, Malik, Abdul, Anis, Itrat, Khan, Sher Bahadar, Ahmed, Ejaz, Ahmed, Zaheer, Nawaz, Sarfraz Ahmad, Choudhary, Muhammad Iqbal
Format: Artikel
Sprache:eng
Schlagworte:
cholinesterase inhibition
lignan
lipoxygenase
Verbinaceae
Vitex negundo
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Zusammenfassung:Two new lignans trivially named negundins A (1) and B (2), were isolated along with (+)-diasyringaresinol (3), (+)-lyoniresinol (4), vitrofolal E (5) and vitrofolal F (6), reported for the first time from this species. The structures of the new compounds were established through spectral studies. Compound 2 showed potent inhibitory activity against lipoxygenase enzyme, while 5 showed moderate activity against butyryl-cholinesterase.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.52.1269