Microbial Metabolites of Harman Alkaloids

Several microorganisms showed the ability to transform the harman alkaloids, harmaline (1), harmalol (2) and harman (5). Harmaline (1) and harmalol (2) were converted by Rhodotorula rubra ATCC 20129 into the tryptamines, 2-acetyl-3-(2-acetamidoethyl)-7-methoxyindole (3) and 2-acetyl-3-(2-acetamidoet...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2003, Vol.51(6), pp.646-648
Hauptverfasser:	Herath, Wimal, Mikell, Julie Rakel, Ferreira, Daneel, Khan, Ikhlas Ahmad
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotransformation Cunninghamella - metabolism General pharmacology harmaline Harmaline - analogs & derivatives Harmaline - metabolism harmalol harman Harmine - analogs & derivatives Harmine - chemistry Harmine - metabolism Magnetic Resonance Spectroscopy Medical sciences metabolites microbial Molecular Structure NMR Pharmacognosy. Homeopathy. Health food Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Rhodotorula - metabolism
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Beschreibung
Zusammenfassung:	Several microorganisms showed the ability to transform the harman alkaloids, harmaline (1), harmalol (2) and harman (5). Harmaline (1) and harmalol (2) were converted by Rhodotorula rubra ATCC 20129 into the tryptamines, 2-acetyl-3-(2-acetamidoethyl)-7-methoxyindole (3) and 2-acetyl-3-(2-acetamidoethyl)-7-hydroxyindole (4), respectively. Harman (5) was biotransformed by Cunninghamella echinulata NRRL 3655 into 6-hydroxyharman (6) and harman-2-oxide (7).
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.51.646